European PRRSpective 2023 session 2 Controlling farm breakdowns
Porcine reproductive and respiratory syndrome virus (is responsible for losses in breeding as well as in growing pig herds and still has an important economic impact on pig production worldwide The objectives of the present study were 1 to establish an infection model with the virulent PRRSV 1 isolate AUT 15 33 in weaned piglets to reproduce symptoms comparable to those observed in the field 2 to assess the efficacy of the MLV vaccine “Ingelvac PRRSFLEX® EU” regarding viral shedding via oral fluids in vaccinated piglets after experimental PRRSV infection with PRRSV strain AUT 15 33 in comparison to non vaccinated piglets and 3 to determine if the dose of infection has an influence on the efficacy of the vaccine.
In this presentation Prof. Enric Mateu shares his knowledge on the Evolution of PRRSv, why this virus recombines and how this is linked to the unusual adaptive immune response.
Prof. Andrea Ladining explains challenge trials with highly virulent PRRSv strains, possible mechanisms of PRRSv transmission from maternal to fetal tissue , what fetal tissue gets infected and how to select the right piglets for taking samples.
Shihan Yuan shows how a classical strain based modifiedlive PRRSV vaccine provide cross-protection against highly pathogenic PRRSV variant associated with porcine high fever disease in China.